Excitability Constraints on Voltage-Gated Sodium Channels
نویسندگان
چکیده
منابع مشابه
Excitability Constraints on Voltage-Gated Sodium Channels
We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathematical models have suggested that sodium channel properties need to be tightly constrained for an action potential to propagate. There are nine mamma...
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Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
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showed that local circuit currents from an excited region Our ability todo gymnastics, to perceive a colorful world, of nerve are needed to bring the next region into activity. and to process language relies on rapid communication This meant that depolarization is the natural stimulus among neurons. Such signaling, the fastest in our bodfor action potential propagation. J. Z. Young (1936) reies...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2007
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.0030177